1q2h: Difference between revisions

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[[Image:1q2h.gif|left|200px]]
{{Seed}}
[[Image:1q2h.png|left|200px]]


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{{STRUCTURE_1q2h|  PDB=1q2h  |  SCENE=  }}  
{{STRUCTURE_1q2h|  PDB=1q2h  |  SCENE=  }}  


'''Phenylalanine Zipper Mediates APS Dimerization'''
===Phenylalanine Zipper Mediates APS Dimerization===




==Overview==
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The APS, SH2-B and LNK proteins are adapters that activate and modulate receptor tyrosine kinase and JAK/STAT signaling. We now show that a conserved N-terminal domain mediates APS homodimerization. We determined the crystal structure of the dimerization domain at a resolution of 1.7 A using bromide ion MAD phasing. Each molecule contributes two helices to a compact four-helix bundle having a bisecting-U topology. Its most conspicuous feature is a stack of interdigitated phenylalanine side chains at the domain core. These residues create a new motif we refer to as a 'phenylalanine zipper,' which is critical to dimerization. A newly developed bridging yeast tri-hybrid assay showed that APS dimerizes JAK2, insulin receptor and IGF1 receptor kinases using its SH2 and dimerization domains. Dimerization via the phenylalanine zipper domain provides a mechanism for activating and modulating tyrosine kinase activity even in the absence of extracellular ligands.
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{{ABSTRACT_PUBMED_15378031}}


==About this Structure==
==About this Structure==
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[[Category: Werner, E D.]]
[[Category: Werner, E D.]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:46:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:41:00 2008''

Revision as of 12:41, 27 July 2008

File:1q2h.png

Template:STRUCTURE 1q2h

Phenylalanine Zipper Mediates APS Dimerization

Template:ABSTRACT PUBMED 15378031

About this Structure

1Q2H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A phenylalanine zipper mediates APS dimerization., Dhe-Paganon S, Werner ED, Nishi M, Hansen L, Chi YI, Shoelson SE, Nat Struct Mol Biol. 2004 Oct;11(10):968-74. Epub 2004 Sep 19. PMID:15378031

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