1oh4: Difference between revisions

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[[Image:1oh4.~~jpg~~|left|200px]]

[[Image:1oh4.png|left|200px]]

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~~'''~~STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE~~'''~~

===STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE===

~~==Overview==~~

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The ~~C-terminal 176 amino acids of a Thermotoga maritima mannanase (Man5) constitute a carbohydrate binding module (CBM) that has been classified into CBM family 27. The isolated CBM27 domain~~, ~~named TmCBM27~~, ~~binds tightly (K(a)s 10(5)-10(6) M(-1))~~ to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. The X-ray crystal structures of native TmCBM27, a TmCBM27-mannohexaose complex, and a TmCBM27-6(~~3),6(4)-alpha-D-galactosyl-mannopentaose complex~~ at 2.~~0 A, 1~~.~~6 A~~, ~~and 1.35 A, respectively, reveal the basis of TmCBM27's specificity for mannans. In particular, the latter complex, which~~ is the first structure of a CBM in complex with a branched plant cell wall polysaccharide, illustrates how the architecture of the binding site can influence the recognition of naturally substituted polysaccharides.

The line below this paragraph, {{ABSTRACT_PUBMED_12791255}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12791255 is the PubMed ID number.

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==About this Structure==

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[[Category: Lectin]]

[[Category: Mannan]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 03~~:50:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:41:00 2008''

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-[[Image:1oh4.jpg|left|200px]]
+{{Seed}}
+[[Image:1oh4.png|left|200px]]
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 {{STRUCTURE_1oh4|  PDB=1oh4  |  SCENE=  }}
-'''STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE'''
+===STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE===
-==Overview==
+<!--
-The C-terminal 176 amino acids of a Thermotoga maritima mannanase (Man5) constitute a carbohydrate binding module (CBM) that has been classified into CBM family 27. The isolated CBM27 domain, named TmCBM27, binds tightly (K(a)s 10(5)-10(6) M(-1)) to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. The X-ray crystal structures of native TmCBM27, a TmCBM27-mannohexaose complex, and a TmCBM27-6(3),6(4)-alpha-D-galactosyl-mannopentaose complex at 2.0 A, 1.6 A, and 1.35 A, respectively, reveal the basis of TmCBM27's specificity for mannans. In particular, the latter complex, which is the first structure of a CBM in complex with a branched plant cell wall polysaccharide, illustrates how the architecture of the binding site can influence the recognition of naturally substituted polysaccharides.
+The line below this paragraph, {{ABSTRACT_PUBMED_12791255}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12791255 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12791255}}
 ==About this Structure==
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 [[Category: Lectin]]
 [[Category: Mannan]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:50:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:41:00 2008''