2f40: Difference between revisions

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[[Image:2f40.gif|left|200px]]
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[[Image:2f40.png|left|200px]]


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{{STRUCTURE_2f40|  PDB=2f40  |  SCENE=  }}  
{{STRUCTURE_2f40|  PDB=2f40  |  SCENE=  }}  


'''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction'''
===Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction===




==Overview==
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Targeting of proteins for structure determination in structural genomic programs often includes the use of threading and fold recognition methods to exclude proteins belonging to well-populated fold families, but such methods can still fail to recognize preexisting folds. The authors illustrate here a method in which limited amounts of structural data are used to improve an initial homology search and the data are subsequently used to produce a structure by data-constrained refinement of an identified structural template. The data used are primarily NMR-based residual dipolar couplings, but they also include additional chemical shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein (PF1455) from Pyrococcus furiosus. Its relationship to existing structures and its probable function are discussed.
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{{ABSTRACT_PUBMED_16927360}}


==About this Structure==
==About this Structure==
2F40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA].  
2F40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA].  


==Reference==
==Reference==
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[[Category: Southeast collaboratory for structural genomic]]
[[Category: Southeast collaboratory for structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:26:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:43:16 2008''

Revision as of 12:43, 27 July 2008

File:2f40.png

Template:STRUCTURE 2f40

Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction

Template:ABSTRACT PUBMED 16927360

About this Structure

2F40 is a Single protein structure of sequence from Pyrococcus furiosus. Full experimental information is available from OCA.

Reference

Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:16927360

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