1q27: Difference between revisions

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[[Image:1q27.gif|left|200px]]
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[[Image:1q27.png|left|200px]]


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{{STRUCTURE_1q27|  PDB=1q27  |  SCENE=  }}  
{{STRUCTURE_1q27|  PDB=1q27  |  SCENE=  }}  


'''NMR Solution Structure of DR0079: An hypothetical Nudix protein from D. radiodurans'''
===NMR Solution Structure of DR0079: An hypothetical Nudix protein from D. radiodurans===




==Overview==
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Using nuclear magnetic resonance (NMR) based methods, including residual dipolar coupling restraints, we have determined the solution structure of the hypothetical Deinococcus radiodurans Nudix protein DR0079 (171 residues, MW = 19.3 kDa). The protein contains eight beta-strands and three alpha-helices organized into three subdomains: an N-terminal beta-sheet (1-34), a central Nudix core (35-140), and a C-terminal helix-turn-helix (141-171). The Nudix core and the C-terminal helix-turn-helix form the fundamental fold common to the Nudix family, a large mixed beta-sheet sandwiched between alpha-helices. The residues that compose the signature Nudix sequence, GX5EX7REUXEEXGU (where U = I, L, or V and X = any amino acid), are contained in a turn-helix-turn motif on the face of the mixed beta-sheet. Chemical shift mapping experiments suggest that DR0079 binds Mg2+. Experiments designed to determine the biological function of the protein indicate that it is not a type I isopentenyl-diphosphate delta-isomerase and that it does not bind alpha,beta-methyleneadenosine 5'-triphosphate (AMPCPP) or guanosine 5'-[beta,gamma-imido]triphosphate (GMPPNP). In this article, the structure of DR0079 is compared to other known Nudix protein structures, a potential substrate-binding surface is proposed, and its possible biological function is discussed.
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==About this Structure==
==About this Structure==
1Q27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q27 OCA].  
1Q27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q27 OCA].  


==Reference==
==Reference==
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[[Category: Nudix hydrolase]]
[[Category: Nudix hydrolase]]
[[Category: Radiation resistance]]
[[Category: Radiation resistance]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:46:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:51:49 2008''

Revision as of 12:51, 27 July 2008

File:1q27.png

Template:STRUCTURE 1q27

NMR Solution Structure of DR0079: An hypothetical Nudix protein from D. radiodurans

Template:ABSTRACT PUBMED 15162484

About this Structure

1Q27 is a Single protein structure of sequence from Deinococcus radiodurans. Full experimental information is available from OCA.

Reference

Solution structure of hypothetical Nudix hydrolase DR0079 from extremely radiation-resistant Deinococcus radiodurans bacterium., Buchko GW, Ni S, Holbrook SR, Kennedy MA, Proteins. 2004 Jul 1;56(1):28-39. PMID:15162484

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