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| {{STRUCTURE_1w24| PDB=1w24 | SCENE= }} | | {{STRUCTURE_1w24| PDB=1w24 | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF HUMAN VPS29'''
| | ===CRYSTAL STRUCTURE OF HUMAN VPS29=== |
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| ==Overview==
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| Vacuolar protein sorting protein 29 (Vps29p), which is involved in retrograde trafficking from prevacuolar endosomes to the trans-Golgi network, performs its biological functions by participating in the formation of a "retromer complex." In human cells, this complex comprises four conserved proteins: hVps35p, hVps29p, hVps26p, and sorting nexin 1 protein (SNX1). Here, we report the crystal structure of hVps29p at 2.1 Angstroms resolution, the first three-dimensional structure of the retromer subunits. This novel structure adopts a four-layered alpha-beta-beta-alpha sandwich fold. hVps29p contains a metal-binding site that is very similar to the active sites of some proteins of the phosphodiesterase/nuclease protein family, indicating that hVps29p may carry out chemically similar functions. Structure and sequence conservation analysis suggests that hVps29p contains two protein-protein interaction sites. One site, which potentially serves as the interface between hVps29p and hVps35p, comprises 5 conserved hydrophobic and 8 hydrophilic residues. The other site is relatively more hydrophilic and may serve as a binding interface with hVps26p, SNX1, or other target proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15788412}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15788412 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15788412}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Alpha-beta-beta-alpha sandwich]] | | [[Category: Alpha-beta-beta-alpha sandwich]] |
| [[Category: Vacuolar protein sorting protein]] | | [[Category: Vacuolar protein sorting protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:02:51 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:54:21 2008'' |
