1qyn: Difference between revisions

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[[Image:1qyn.gif|left|200px]]
{{Seed}}
[[Image:1qyn.png|left|200px]]


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{{STRUCTURE_1qyn|  PDB=1qyn  |  SCENE=  }}  
{{STRUCTURE_1qyn|  PDB=1qyn  |  SCENE=  }}  


'''Crystal Structure of SecB from Escherichia coli'''
===Crystal Structure of SecB from Escherichia coli===




==Overview==
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The chaperone SecB from Escherichia coli is primarily involved in passing precursor proteins into the Sec system via specific interactions with SecA. The crystal structure of SecB from E. coli has been solved to 2.35 A resolution. The structure shows flexibility in the crossover loop and the helix-connecting loop, regions that have been implicated to be part of the SecB substrate-binding site. Moreover conformational variability of Trp36 is observed as well as different loop conformations for the different monomers. Based on this, we speculate that SecB can regulate the access or extent of its hydrophobic substrate-binding site, by modulating the conformation of the crossover loop and the helix-connecting loop. The structure also clearly explains why the tetrameric equilibrium is shifted towards the dimeric state in the mutant SecBCys76Tyr. The buried cysteine residue is crucial for tight packing, and mutations are likely to disrupt the tetramer formation but not the dimer formation.
The line below this paragraph, {{ABSTRACT_PUBMED_14643199}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_14643199}}


==About this Structure==
==About this Structure==
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[[Category: Greek key beta sheet]]
[[Category: Greek key beta sheet]]
[[Category: Tetramer]]
[[Category: Tetramer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:51:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:54:42 2008''

Revision as of 12:54, 27 July 2008

File:1qyn.png

Template:STRUCTURE 1qyn

Crystal Structure of SecB from Escherichia coli

Template:ABSTRACT PUBMED 14643199

About this Structure

1QYN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of SecB from Escherichia coli., Dekker C, de Kruijff B, Gros P, J Struct Biol. 2003 Dec;144(3):313-9. PMID:14643199

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