2q9y: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Newer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_2q9y", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2q9y.jpg|left|200px]]
{{Seed}}
[[Image:2q9y.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2q9y|  PDB=2q9y  |  SCENE=  }}  
{{STRUCTURE_2q9y|  PDB=2q9y  |  SCENE=  }}  


'''Trichodiene synthase: Complex with Mg, inorganic pyrophosphate, and benzyl triethyl ammonium cation'''
===Trichodiene synthase: Complex with Mg, inorganic pyrophosphate, and benzyl triethyl ammonium cation===




==Overview==
<!--
Trichodiene synthase is a terpenoid cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to form the bicyclic sesquiterpene hydrocarbon trichodiene (89%), at least five sesquiterpene side products (11%), and inorganic pyrophosphate (PP(i)). Incubation of trichodiene synthase with 2-fluorofarnesyl diphosphate or 4-methylfarnesyl diphosphate similarly yields sesquiterpene mixtures despite the electronic effects or steric bulk introduced by substrate derivatization. The versatility of the enzyme is also demonstrated in the 2.85A resolution X-ray crystal structure of the complex with Mg(2+) (3)-PP(i) and the benzyl triethylammonium cation, which is a bulkier mimic of the bisabolyl carbocation intermediate in catalysis. Taken together, these findings show that the active site of trichodiene synthase is sufficiently flexible to accommodate bulkier and electronically-diverse substrates and intermediates, which could indicate additional potential for the biosynthetic utility of this terpenoid cyclase.
The line below this paragraph, {{ABSTRACT_PUBMED_17678871}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17678871 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17678871}}


==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Terpenoid synthase fold]]
[[Category: Terpenoid synthase fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:40:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:55:34 2008''
Retrieved from "https://proteopedia.org/2q9y"