2jet: Difference between revisions

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[[Image:2jet.jpg|left|200px]]
{{Seed}}
[[Image:2jet.png|left|200px]]


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{{STRUCTURE_2jet|  PDB=2jet  |  SCENE=  }}  
{{STRUCTURE_2jet|  PDB=2jet  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A TRYPSIN-LIKE MUTANT (S189D, A226G) CHYMOTRYPSIN.'''
===CRYSTAL STRUCTURE OF A TRYPSIN-LIKE MUTANT (S189D, A226G) CHYMOTRYPSIN.===




==Overview==
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The crystal structure of the S189D+A226G rat chymotrypsin-B mutant has been determined at 2.2 A resolution. This mutant is the most trypsin-like mutant so far in the line of chymotrypsin-to-trypsin conversions, aiming for a more complete understanding of the structural basis of substrate specificity in pancreatic serine proteases. A226G caused significant rearrangements relative to S189D chymotrypsin, allowing an internal conformation of Asp189 which is close to that in trypsin. Serious distortions remain, however, in the activation domain, including zymogen-like features. The pH-profile of activity suggests that the conformation of the S1-site of the mutant is influenced also by the P1 residue of the substrate.
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{{ABSTRACT_PUBMED_17805946}}


==About this Structure==
==About this Structure==
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[[Category: Substrate specificity]]
[[Category: Substrate specificity]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:48:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:57:35 2008''

Revision as of 12:57, 27 July 2008

File:2jet.png

Template:STRUCTURE 2jet

CRYSTAL STRUCTURE OF A TRYPSIN-LIKE MUTANT (S189D, A226G) CHYMOTRYPSIN.

Template:ABSTRACT PUBMED 17805946

About this Structure

2JET is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The Crystal Structure of a Trypsin-like Mutant Chymotrypsin: The Role of Position 226 in the Activity and Specificity of S189D Chymotrypsin., Jelinek B, Katona G, Fodor K, Venekei I, Graf L, Protein J. 2007 Sep 6;. PMID:17805946

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