1qmc: Difference between revisions

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[[Image:1qmc.~~gif~~|left|200px]]

[[Image:1qmc.png|left|200px]]

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~~'''~~C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES~~'''~~

===C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES===

~~==Overview==~~

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~~The structure of the C~~-~~terminal DNA~~-~~binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy.~~ The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the ~~structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus~~ the ~~average of 0~~.~~46 A~~. ~~Correlation of~~ the ~~structure with recent mutagenesis studies suggests two possible models for DNA binding~~. ~~Proteins 1999;36:556~~-~~564.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10450096}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10450096 is the PubMed ID number.

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==About this Structure==

1QMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA].

1QMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA].

==Reference==

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[[Category: Integrase]]

[[Category: Polyprotein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:26:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:15:29 2008''

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-[[Image:1qmc.gif|left|200px]]
+{{Seed}}
+[[Image:1qmc.png|left|200px]]
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 {{STRUCTURE_1qmc|  PDB=1qmc  |  SCENE=  }}
-'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES'''
+===C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES===
-==Overview==
+<!--
-The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564.
+The line below this paragraph, {{ABSTRACT_PUBMED_10450096}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10450096 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10450096}}
 ==About this Structure==
-QMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA].
+QMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA].
 ==Reference==
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 [[Category: Integrase]]
 [[Category: Polyprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:26:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:15:29 2008''