1n8j: Difference between revisions

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[[Image:1n8j.gif|left|200px]]
{{Seed}}
[[Image:1n8j.png|left|200px]]


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{{STRUCTURE_1n8j|  PDB=1n8j  |  SCENE=  }}  
{{STRUCTURE_1n8j|  PDB=1n8j  |  SCENE=  }}  


'''Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)'''
===Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)===




==Overview==
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Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to regulate hydrogen peroxide-mediated signal transduction. We show that bacterial 2-Cys Prxs are much less sensitive to oxidative inactivation than are eukaryotic 2-Cys Prxs. By identifying two sequence motifs unique to the sensitive 2-Cys Prxs and comparing the crystal structure of a bacterial 2-Cys Prx at 2.2 angstrom resolution with other Prx structures, we define the structural origins of sensitivity. We suggest this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction.
The line below this paragraph, {{ABSTRACT_PUBMED_12714747}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12714747}}


==About this Structure==
==About this Structure==
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[[Category: Peroxidase]]
[[Category: Peroxidase]]
[[Category: Peroxiredoxin]]
[[Category: Peroxiredoxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:13:38 2008''
 
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