2hmu: Difference between revisions

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[[Image:2hmu.~~jpg~~|left|200px]]

[[Image:2hmu.png|left|200px]]

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~~'''~~Diamond-shaped octameric ring structure of an RCK domain with ATP bound~~'''~~

===Diamond-shaped octameric ring structure of an RCK domain with ATP bound===

~~==Overview==~~

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The ~~KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA~~, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, ~~tetramer versus octamer. Our results for~~ the ~~KtrAB RCK domain clearly show an octamer in solution and in~~ the ~~crystal~~. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. ~~We present experimental evidence for~~ the ~~association between one RCK octameric ring and two KtrB membrane proteins~~. ~~These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK~~-~~domain octameric ring model is generally applicable to other ion~~-~~transport systems.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16990138}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16990138 is the PubMed ID number.

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==About this Structure==

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[[Category: Rck]]

[[Category: Symporter]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 06~~:28:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:32:10 2008''

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-[[Image:2hmu.jpg|left|200px]]
+{{Seed}}
+[[Image:2hmu.png|left|200px]]
 <!--
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 {{STRUCTURE_2hmu|  PDB=2hmu  |  SCENE=  }}
-'''Diamond-shaped octameric ring structure of an RCK domain with ATP bound'''
+===Diamond-shaped octameric ring structure of an RCK domain with ATP bound===
-==Overview==
+<!--
-The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems.
+The line below this paragraph, {{ABSTRACT_PUBMED_16990138}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16990138 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16990138}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Rck]]
 [[Category: Symporter]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:28:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:32:10 2008''