2bn6: Difference between revisions

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[[Image:2bn6.gif|left|200px]]
{{Seed}}
[[Image:2bn6.png|left|200px]]


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{{STRUCTURE_2bn6|  PDB=2bn6  |  SCENE=  }}  
{{STRUCTURE_2bn6|  PDB=2bn6  |  SCENE=  }}  


'''P-ELEMENT SOMATIC INHIBITOR PROTEIN'''
===P-ELEMENT SOMATIC INHIBITOR PROTEIN===




==Overview==
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P-element transposition in Drosophila is regulated by tissue-specific alternative splicing of the P-element transposase pre-mRNA. In somatic cells, the P-element somatic inhibitor (PSI) protein binds to exon 3 of the pre-mRNA and recruits U1 small nuclear ribonucleoprotein (snRNP) to the F1 pseudo-splice site. This abrogates binding of U1 snRNP to the genuine 5' splice site, thereby preventing excision of the third intron. Two homologous short sequences, referred to as the A and B boxes, near the C terminus of PSI bind to U1-70k protein within U1 snRNP. We have now mapped the AB box-binding site of U1-70k to a short proline-rich sequence at the C terminus. Our NMR study shows that the B box forms an anti-parallel helical hairpin in which four highly conserved aromatic residues form a cluster on one face of the first helix. This hydrophobic cluster interacts extensively with the proline-rich region of the U1-70k protein.
The line below this paragraph, {{ABSTRACT_PUBMED_15990112}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15990112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15990112}}


==About this Structure==
==About this Structure==
2BN6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN6 OCA].  
2BN6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN6 OCA].  


==Reference==
==Reference==
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[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
[[Category: Splicing]]
[[Category: Splicing]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:31:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:38:46 2008''

Revision as of 13:38, 27 July 2008

File:2bn6.png

Template:STRUCTURE 2bn6

P-ELEMENT SOMATIC INHIBITOR PROTEIN

Template:ABSTRACT PUBMED 15990112

About this Structure

2BN6 is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase., Ignjatovic T, Yang JC, Butler J, Neuhaus D, Nagai K, J Mol Biol. 2005 Aug 5;351(1):52-65. PMID:15990112

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