2c1h: Difference between revisions

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[[Image:2c1h.jpg|left|200px]]
{{Seed}}
[[Image:2c1h.png|left|200px]]


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{{STRUCTURE_2c1h|  PDB=2c1h  |  SCENE=  }}  
{{STRUCTURE_2c1h|  PDB=2c1h  |  SCENE=  }}  


'''THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR'''
===THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR===




==Overview==
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The structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase (ALAD) complexed with the irreversible inhibitor 4,7-dioxosebacic acid has been solved. The inhibitor binds by forming Schiff-base linkages with lysines 200 and 253 at the active site. The structure reported here provides a definition of the interactions made by both of the substrate molecules (A-side and P-side substrates) with the C. vibrioforme ALAD and is compared and contrasted with structures of the same inhibitor bound to Escherichia coli and yeast ALAD. The structure suggests why 4,7-dioxosebacic acid is a better inhibitor of the zinc-dependent ALADs than of the zinc-independent ALADs.
The line below this paragraph, {{ABSTRACT_PUBMED_16304458}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16304458}}


==About this Structure==
==About this Structure==
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[[Category: Magnesium]]
[[Category: Magnesium]]
[[Category: Porphyrin biosynthesis]]
[[Category: Porphyrin biosynthesis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:06:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:44:38 2008''

Revision as of 13:44, 27 July 2008

File:2c1h.png

Template:STRUCTURE 2c1h

THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR

Template:ABSTRACT PUBMED 16304458

About this Structure

2C1H is a Single protein structure of sequence from Prosthecochloris vibrioformis. Full crystallographic information is available from OCA.

Reference

Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor., Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005, Nov 19. PMID:16304458

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