1sg6: Difference between revisions

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[[Image:1sg6.gif|left|200px]]
{{Seed}}
[[Image:1sg6.png|left|200px]]


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{{STRUCTURE_1sg6|  PDB=1sg6  |  SCENE=  }}  
{{STRUCTURE_1sg6|  PDB=1sg6  |  SCENE=  }}  


'''Crystal structure of Aspergillus nidulans 3-dehydroquinate synthase (AnDHQS) in complex with Zn2+ and NAD+, at 1.7D'''
===Crystal structure of Aspergillus nidulans 3-dehydroquinate synthase (AnDHQS) in complex with Zn2+ and NAD+, at 1.7D===




==Overview==
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Crystallization of Aspergillus nidulans 3-dehydroquinate synthase (DHQS), following turnover of the enzyme by addition of the substrate DAHP, gave a new crystal form (form J). Although the crystals have dimensions of only 50 x 20 x 5 micro m, they are well ordered, diffracting to 1.7 A. The space group is C222(1), with unit-cell parameters a = 90.0, b = 103.7, c = 177.4 A. Structure determination and refinement to R = 0.19 (R(free) = 0.25) shows the DHQS is in the 'open' form with the substrate site unoccupied but with some loop regions perturbed. Previous crystals of open-form DHQS only diffracted to 2.5 A resolution. The use of enzyme turnover may be applicable in other systems in attempts to improve crystal quality.
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==About this Structure==
==About this Structure==
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[[Category: Open form]]
[[Category: Open form]]
[[Category: Shikimate pathway]]
[[Category: Shikimate pathway]]
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