2fme: Difference between revisions

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[[Image:2fme.gif|left|200px]]
{{Seed}}
[[Image:2fme.png|left|200px]]


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{{STRUCTURE_2fme|  PDB=2fme  |  SCENE=  }}  
{{STRUCTURE_2fme|  PDB=2fme  |  SCENE=  }}  


'''Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide'''
===Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide===




==Overview==
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In a high-throughput screening effort, a series of tetrahydroisoquinolines was identified as modest inhibitors of human Eg5. A medicinal chemistry optimization effort led to the identification of R-4-(3-hydroxyphenyl)-N,N-7,8-tetramethyl-3,4-dihydroisoquinoline-2(1H)-ca rboxamide (32a) as a potent inhibitor of human Eg5 (ATPase IC50 104 nM) with good anti-proliferative activity in A2780 cells (IC50 234 nM).
The line below this paragraph, {{ABSTRACT_PUBMED_16458511}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16458511 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16458511}}


==About this Structure==
==About this Structure==
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[[Category: Sheriff, S.]]
[[Category: Sheriff, S.]]
[[Category: Eg5 ksp mg-adp complex inhibitor]]
[[Category: Eg5 ksp mg-adp complex inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:04:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:10:27 2008''
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