2by4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,097 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,097 edits
No edit summary
Line 1: Line 1:
[[Image:2by4.gif|left|200px]]
{{Seed}}
[[Image:2by4.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2by4|  PDB=2by4  |  SCENE=  }}  
{{STRUCTURE_2by4|  PDB=2by4  |  SCENE=  }}  


'''SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.'''
===SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.===




==Overview==
<!--  
An analysis of the binding of the 8-O-N-tert-butoxycarbonyl-12-aminododecanoyl derivative of 8-O-debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O-8. Based on the analysis a series of analogues to the 2-unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12-Boc-aminododecaonoyl derivative, however, was found to be apoptotic.
The line below this paragraph, {{ABSTRACT_PUBMED_16412648}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16412648 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16412648}}


==About this Structure==
==About this Structure==
Line 49: Line 53:
[[Category: Thapsigargin]]
[[Category: Thapsigargin]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:57:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:23:20 2008''

Revision as of 14:23, 27 July 2008

File:2by4.png

Template:STRUCTURE 2by4

SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.

Template:ABSTRACT PUBMED 16412648

About this Structure

2BY4 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells., Sohoel H, Jensen AM, Moller JV, Nissen P, Denmeade SR, Isaacs JT, Olsen CE, Christensen SB, Bioorg Med Chem. 2006 Apr 15;14(8):2810-5. Epub 2006 Jan 10. PMID:16412648

Page seeded by OCA on Sun Jul 27 17:23:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2by4&oldid=658067"