2pmi: Difference between revisions

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[[Image:2pmi.jpg|left|200px]]
{{Seed}}
[[Image:2pmi.png|left|200px]]


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{{STRUCTURE_2pmi|  PDB=2pmi  |  SCENE=  }}  
{{STRUCTURE_2pmi|  PDB=2pmi  |  SCENE=  }}  


'''Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S'''
===Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S===




==Overview==
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The ability to sense and respond appropriately to environmental changes is a primary requirement of all living organisms. In response to phosphate limitation, Saccharomyces cerevisiae induces transcription of a set of genes involved in the regulation of phosphate acquisition from the ambient environment. A signal transduction pathway (the PHO pathway) mediates this response, with Pho85-Pho80 playing a vital role. Here we report the X-ray structure of Pho85-Pho80, a prototypic structure of a CDK-cyclin complex functioning in transcriptional regulation in response to environmental changes. The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition. It further showed two sites on the Pho80 cyclin for high-affinity binding of the transcription factor substrate (Pho4) and the CDK inhibitor (Pho81) that are markedly distant to each other and the active site.
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{{ABSTRACT_PUBMED_18042456}}


==About this Structure==
==About this Structure==
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[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Signaling protein,transferase/cell cycle complex]]
[[Category: Signaling protein,transferase/cell cycle complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:25:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:23:58 2008''

Revision as of 14:24, 27 July 2008

File:2pmi.png

Template:STRUCTURE 2pmi

Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S

Template:ABSTRACT PUBMED 18042456

About this Structure

2PMI is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway., Huang K, Ferrin-O'Connell I, Zhang W, Leonard GA, O'Shea EK, Quiocho FA, Mol Cell. 2007 Nov 30;28(4):614-23. PMID:18042456

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