1s3t: Difference between revisions

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[[Image:1s3t.gif|left|200px]]
{{Seed}}
[[Image:1s3t.png|left|200px]]


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{{STRUCTURE_1s3t|  PDB=1s3t  |  SCENE=  }}  
{{STRUCTURE_1s3t|  PDB=1s3t  |  SCENE=  }}  


'''BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE'''
===BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE===




==Overview==
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The structure of the complex of urease, a Ni-containing metalloenzyme, with boric acid was determined at 2.10 A resolution. The complex shows the unprecedented binding mode of the competitive inhibitor to the dinuclear metal center, with the B(OH)3 molecule bridging the Ni ions and leaving in place the bridging hydroxide. Boric acid can be considered a substrate analogue of urea, and the structure supports the proposal that the Ni-bridging hydroxide acts as the nucleophile in the enzymatic process of urea hydrolysis.
The line below this paragraph, {{ABSTRACT_PUBMED_15038715}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15038715}}


==About this Structure==
==About this Structure==
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[[Category: Nickel]]
[[Category: Nickel]]
[[Category: Urease]]
[[Category: Urease]]
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