1ncj: Difference between revisions

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[[Image:1ncj.gif|left|200px]]
{{Seed}}
[[Image:1ncj.png|left|200px]]


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{{STRUCTURE_1ncj|  PDB=1ncj  |  SCENE=  }}  
{{STRUCTURE_1ncj|  PDB=1ncj  |  SCENE=  }}  


'''N-CADHERIN, TWO-DOMAIN FRAGMENT'''
===N-CADHERIN, TWO-DOMAIN FRAGMENT===




==Overview==
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To investigate the possible biological function of the lateral "strand dimer" observed in crystal structures of a D1 domain extracellular fragment from N-cadherin, we have undertaken site-directed mutagenesis studies of this molecule. Mutation of most residues important in the strand dimer interface abolish the ability of N-cadherin to mediate cell adhesion. Mutation of an analogous central residue (Trp-2) in E-cadherin also abrogates the adhesive capacity of that molecule. We also determined the crystal structure of a Ca2+-complexed two-domain fragment from N-cadherin. This structure, like its E-cadherin counterpart, does not adopt the strand dimer conformation. This suggests the possibility that classical cadherins might stably exist in both dimeric and monomeric forms. Data from several laboratories imply that lateral dimerization or clustering of cadherins may increase their adhesivity. We suggest the possibility that the strand dimer may play a role in this activation.
The line below this paragraph, {{ABSTRACT_PUBMED_9655503}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9655503}}


==About this Structure==
==About this Structure==
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[[Category: Tamura, K.]]
[[Category: Tamura, K.]]
[[Category: Cell adhesion protein]]
[[Category: Cell adhesion protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:22:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:44:26 2008''

Revision as of 14:44, 27 July 2008

File:1ncj.png

Template:STRUCTURE 1ncj

N-CADHERIN, TWO-DOMAIN FRAGMENT

Template:ABSTRACT PUBMED 9655503

About this Structure

1NCJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure-function analysis of cell adhesion by neural (N-) cadherin., Tamura K, Shan WS, Hendrickson WA, Colman DR, Shapiro L, Neuron. 1998 Jun;20(6):1153-63. PMID:9655503

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