2ekv: Difference between revisions

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[[Image:2ekv.jpg|left|200px]]
{{Seed}}
[[Image:2ekv.png|left|200px]]


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{{STRUCTURE_2ekv|  PDB=2ekv  |  SCENE=  }}  
{{STRUCTURE_2ekv|  PDB=2ekv  |  SCENE=  }}  


'''The crystal structure of rigor like squid myosin S1 in the absence of nucleotide'''
===The crystal structure of rigor like squid myosin S1 in the absence of nucleotide===




==Overview==
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Unlike processive cellular motors such as myosin V, whose structure has recently been determined in a "rigor-like" conformation, myosin II from contracting muscle filaments necessarily spends most of its time detached from actin. By using squid and sea scallop sources, however, we have now obtained similar rigor-like atomic structures for muscle myosin heads (S1). The significance of the hallmark closed actin-binding cleft in these crystal structures is supported here by actin/S1-binding studies. These structures reveal how different duty ratios, and hence cellular functions, of the myosin isoforms may be accounted for, in part, on the basis of detailed differences in interdomain contacts. Moreover, the rigor-like position of switch II turns out to be unique for myosin V. The overall arrangements of subdomains in the motor are relatively conserved in each of the known contractile states, and we explore qualitatively the energetics of these states.
The line below this paragraph, {{ABSTRACT_PUBMED_17502101}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17502101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17502101}}


==About this Structure==
==About this Structure==
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[[Category: Rigor-like]]
[[Category: Rigor-like]]
[[Category: Squid]]
[[Category: Squid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 02:41:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:47:06 2008''

Revision as of 14:47, 27 July 2008

File:2ekv.png

Template:STRUCTURE 2ekv

The crystal structure of rigor like squid myosin S1 in the absence of nucleotide

Template:ABSTRACT PUBMED 17502101

About this Structure

2EKV is a Protein complex structure of sequences from Loligo pealei and Todarodes pacificus. Full crystallographic information is available from OCA.

Reference

Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor., Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C, Structure. 2007 May;15(5):553-64. PMID:17502101

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