2g2k: Difference between revisions

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[[Image:2g2k.gif|left|200px]]
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[[Image:2g2k.png|left|200px]]


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{{STRUCTURE_2g2k|  PDB=2g2k  |  SCENE=  }}  
{{STRUCTURE_2g2k|  PDB=2g2k  |  SCENE=  }}  


'''NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5)'''
===NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5)===




==Overview==
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Eukaryotic initiation factor 5 (eIF5) plays multiple roles in translation initiation. Its N-terminal domain functions as a GTPase-activator protein (GAP) for GTP bound to eIF2, while its C-terminal region nucleates the interactions between multiple translation factors, including eIF1, which acts to inhibit GTP hydrolysis or P(i) release, and the beta subunit of eIF2. These proteins and the events in which they participate are critical for the accurate recognition of the correct start codon during translation initiation. Here, we report the three-dimensional solution structure of the N-terminal domain of human eIF5, comprising two subdomains, both reminiscent of nucleic-acid-binding modules. The N-terminal subdomain contains the "arginine finger" motif that is essential for GAP function but which, unusually, resides in a partially disordered region of the molecule. This implies that a conformational reordering of this portion of eIF5 is likely to occur upon formation of a competent complex for GTP hydrolysis, following the appropriate activation signal. Interestingly, the N-terminal subdomain of eIF5 reveals an alpha/beta fold structurally similar to both the archaeal orthologue of the beta subunit of eIF2 and, unexpectedly, to eIF1. These results reveal a novel protein fold common to several factors involved in related steps of translation initiation. The implications of these observations are discussed in terms of the mechanism of translation initiation.
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{{ABSTRACT_PUBMED_16584190}}


==About this Structure==
==About this Structure==
2G2K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2K OCA].  
2G2K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2K OCA].  


==Reference==
==Reference==
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[[Category: Eif125 fold]]
[[Category: Eif125 fold]]
[[Category: Eif5]]
[[Category: Eif5]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:37:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:54:59 2008''

Revision as of 14:55, 27 July 2008

File:2g2k.png

Template:STRUCTURE 2g2k

NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5)

Template:ABSTRACT PUBMED 16584190

About this Structure

2G2K is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors., Conte MR, Kelly G, Babon J, Sanfelice D, Youell J, Smerdon SJ, Proud CG, Biochemistry. 2006 Apr 11;45(14):4550-8. PMID:16584190

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