2okh: Difference between revisions

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[[Image:2okh.gif|left|200px]]
{{Seed}}
[[Image:2okh.png|left|200px]]


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{{STRUCTURE_2okh|  PDB=2okh  |  SCENE=  }}  
{{STRUCTURE_2okh|  PDB=2okh  |  SCENE=  }}  


'''Crystal structure of dimeric form of PfFabZ in crystal form3'''
===Crystal structure of dimeric form of PfFabZ in crystal form3===




==Overview==
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The crystals obtained from various batches of crystallization trials of FabZ from Plasmodium falciparum exhibited non-isomorphism. The c axis of the I222 cell showed a large variation of about 16 A, from c = 81 A to c = 97 A. Complete data sets were collected for three crystal forms with varying lengths of the c axis (form 1, c = 97 A; form 2, c = 92 A; form 3, c = 81 A). The crystal structure of form 1 has been reported previously. Here, the crystal structures of the other two crystal forms are reported and a detailed structural comparison is made of the three crystal forms in order to explore the possible reasons for the existence of non-isomorphism. The conformations of three loops vary between the three crystal forms. The disposition of the loops affects the crystal packing and hence the unit-cell parameter. The crystallization condition and crystallization method employed, which change the evaporation rate, determine the crystal form of the enzyme. The present analysis shows that pH-induced intrinsic conformational changes in the protein play a key role in the observed differences.
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{{ABSTRACT_PUBMED_17372349}}


==About this Structure==
==About this Structure==
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[[Category: Non-isomorphism]]
[[Category: Non-isomorphism]]
[[Category: Plasmodium]]
[[Category: Plasmodium]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:05:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:59:35 2008''

Revision as of 14:59, 27 July 2008

File:2okh.png

Template:STRUCTURE 2okh

Crystal structure of dimeric form of PfFabZ in crystal form3

Template:ABSTRACT PUBMED 17372349

About this Structure

2OKH is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum., Swarnamukhi PL, Sharma SK, Padala P, Surolia N, Surolia A, Suguna K, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):458-64. Epub 2007, Mar 16. PMID:17372349

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