1uos: Difference between revisions

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[[Image:1uos.~~gif~~|left|200px]]

[[Image:1uos.png|left|200px]]

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~~'''~~THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN~~'''~~

===THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN===

~~==Overview==~~

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~~Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation.~~ The ~~snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI~~, ~~the platelet receptor for collagen, and triggers signal transduction. Here~~, the ~~2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms~~ to the ~~C-type lectin-fold topology~~. ~~Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding~~. ~~Unlike other family members, with the exception of flavocetin-A (FL-A~~), ~~Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure~~ is ~~consistent with Cvx clustering GPVI molecules on~~ the ~~surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly~~.

The line below this paragraph, {{ABSTRACT_PUBMED_14684891}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14684891 is the PubMed ID number.

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==About this Structure==

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[[Category: Structural genomic]]

[[Category: Structural proteomics in europe]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Apr 13 08~~:12:30 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:09:04 2008''

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-[[Image:1uos.gif|left|200px]]
+{{Seed}}
+[[Image:1uos.png|left|200px]]
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 {{STRUCTURE_1uos|  PDB=1uos  |  SCENE=  }}
-'''THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN'''
+===THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN===
-==Overview==
+<!--
-Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation. The snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI, the platelet receptor for collagen, and triggers signal transduction. Here, the 2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms to the C-type lectin-fold topology. Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding. Unlike other family members, with the exception of flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure is consistent with Cvx clustering GPVI molecules on the surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly.
+The line below this paragraph, {{ABSTRACT_PUBMED_14684891}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14684891 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14684891}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Structural genomic]]
 [[Category: Structural proteomics in europe]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:12:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:09:04 2008''