2bkz: Difference between revisions

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[[Image:2bkz.gif|left|200px]]
{{Seed}}
[[Image:2bkz.png|left|200px]]


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{{STRUCTURE_2bkz|  PDB=2bkz  |  SCENE=  }}  
{{STRUCTURE_2bkz|  PDB=2bkz  |  SCENE=  }}  


'''STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611'''
===STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611===




==Overview==
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The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.
The line below this paragraph, {{ABSTRACT_PUBMED_15713378}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15713378 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15713378}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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