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| [[Image:2q7f.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2q7f| PDB=2q7f | SCENE= }} | | {{STRUCTURE_2q7f| PDB=2q7f | SCENE= }} |
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| '''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site'''
| | ===Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site=== |
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| ==Overview==
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| YrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17624311}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17624311 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17624311}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Tpr]] | | [[Category: Tpr]] |
| [[Category: Yrrb]] | | [[Category: Yrrb]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:28:52 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:16:28 2008'' |
