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| '''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4'''
| | ===CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4=== |
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| ==Overview==
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| The crystal structure of recombinant human interleukin-4 (rhuIL-4) was initially determined at 3.5-A resolution by multiple isomorphous replacement techniques and subsequently refined to a resolution of 2.35 A by simulated annealing. The final crystallographic R-factor, based on all data in the range 6.0-2.35 A (7470 reflections), is 0.232. Bond lengths and bond angles in the molecule have root mean square deviations from ideal values of 0.016 A and 2.4 degrees, respectively. The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhuIL-4 is a four alpha-helix bundle, which composes approximately 58% of the structure. The helices are arranged in a left-handed antiparallel bundle with two overhand connections. Within these connections is a two-stranded antiparallel beta-sheet. Both the tertiary and secondary structures of rhuIL-4 are similar to those of human granulocyte-macrophage colony-stimulating factor. Critical regions for receptor binding are proposed.
| | The line below this paragraph, {{ABSTRACT_PUBMED_1400355}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 1400355 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_1400355}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Zhao, B G.]] | | [[Category: Zhao, B G.]] |
| [[Category: Cytokine]] | | [[Category: Cytokine]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:41:48 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:18:01 2008'' |
