2iiv: Difference between revisions

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-[[Image:2iiv.gif|left|200px]]
+{{Seed}}
+[[Image:2iiv.png|left|200px]]
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 {{STRUCTURE_2iiv|  PDB=2iiv  |  SCENE=  }}
-'''Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor'''
+===Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor===
-==Overview==
+<!--
-Replacement of the triazolopiperazine ring of sitagliptin (DPP-4 IC(50)=18nM) with 3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one gave dipeptidyl peptidase IV (DPP-4) inhibitor 1 which is potent (DPP-4 IC(50)=2.6nM), selective, and efficacious in an oral glucose tolerance test in mice. It was selected for extensive preclinical development as a potential back-up candidate to sitagliptin.
+The line below this paragraph, {{ABSTRACT_PUBMED_17055272}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17055272 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17055272}}
 ==About this Structure==
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 [[Category: Dimer]]
 [[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:33:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:18:43 2008''

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