1tu5: Difference between revisions

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[[Image:1tu5.gif|left|200px]]
{{Seed}}
[[Image:1tu5.png|left|200px]]


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{{STRUCTURE_1tu5|  PDB=1tu5  |  SCENE=  }}  
{{STRUCTURE_1tu5|  PDB=1tu5  |  SCENE=  }}  


'''Crystal structure of bovine plasma copper-containing amine oxidase'''
===Crystal structure of bovine plasma copper-containing amine oxidase===




==Overview==
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Copper-containing amine oxidase extracted from bovine serum (BSAO) was crystallized and its three-dimensional structure at 2.37A resolution is described. The biological unit of BSAO is a homodimer, formed by two monomers related to each other by a non-crystallographic 2-fold axis. Each monomer is composed of three domains, similar to those of other amine oxidases from lower species. The two monomers are structurally equivalent, despite some minor differences at the two active sites. A large funnel allows access of substrates to the active-site; another cavity, accessible to the solvent, is also present between the two monomers; this second cavity could allow the entrance of molecular oxygen necessary for the oxidative reaction. Some sugar residues, bound to Asn, were still present and visible in the electron density map, in spite of the exhaustive deglycosylation necessary to grow the crystals. The comparison of the BSAO structure with those of other resolved AO structures shows strong dissimilarities in the architecture and charge distribution of the cavities leading to the active-site, possibly explaining the differences in substrate specificity.
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of amine oxidase from bovine serum., Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G, J Mol Biol. 2005 Mar 4;346(4):991-1004. Epub 2005 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15701511 15701511]
Crystal structure of amine oxidase from bovine serum., Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G, J Mol Biol. 2005 Mar 4;346(4):991-1004. Epub 2005 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15701511 15701511]
Crystallization and preliminary X-ray data of amine oxidase from bovine serum., Calderone V, Di Paolo ML, Trabucco M, Biadene M, Battistutta R, Rigo A, Zanotti G, Acta Crystallogr D Biol Crystallogr. 2003 Apr;59(Pt 4):727-9. Epub 2003, Mar 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12657794 12657794]
Copper amine oxidase: a novel use for a tyrosine., Fontecave M, Eklund H, Structure. 1995 Nov 15;3(11):1127-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8591022 8591022]
Crystal structure of a eukaryotic (pea seedling) copper-containing amine oxidase at 2.2 A resolution., Kumar V, Dooley DM, Freeman HC, Guss JM, Harvey I, McGuirl MA, Wilce MC, Zubak VM, Structure. 1996 Aug 15;4(8):943-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805580 8805580]
The crystal structure of Pichia pastoris lysyl oxidase., Duff AP, Cohen AE, Ellis PJ, Kuchar JA, Langley DB, Shepard EM, Dooley DM, Freeman HC, Guss JM, Biochemistry. 2003 Dec 30;42(51):15148-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14690425 14690425]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Quinoenzyme]]
[[Category: Quinoenzyme]]
[[Category: Tpq]]
[[Category: Tpq]]
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