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| {{STRUCTURE_1xiw| PDB=1xiw | SCENE= }} | | {{STRUCTURE_1xiw| PDB=1xiw | SCENE= }} |
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| '''Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment'''
| | ===Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment=== |
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| ==Overview==
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| The alpha/beta T cell receptor complex transmits signals from MHC/peptide antigens through a set of constitutively associated signaling molecules, including CD3-epsilon/gamma and CD3-epsilon/delta. We report the crystal structure at 1.9-A resolution of a complex between a human CD3-epsilon/delta ectodomain heterodimer and a single-chain fragment of the UCHT1 antibody. CD3-epsilon/delta and CD3-epsilon/gamma share a conserved interface between the Ig-fold ectodomains, with parallel packing of the two G strands. CD3-delta has a more electronegative surface and a more compact Ig fold than CD3-gamma; thus, the two CD3 heterodimers have distinctly different molecular surfaces. The UCHT1 antibody binds near an acidic region of CD3-epsilon opposite the dimer interface, occluding this region from direct interaction with the TCR. This immunodominant epitope may be a uniquely accessible surface in the TCR/CD3 complex, because there is overlap between the binding site of the UCHT1 and OKT3 antibodies. Determination of the CD3-epsilon/delta structure completes the set of TCR/CD3 globular ectodomains and contributes information about exposed CD3 surfaces. | | The line below this paragraph, {{ABSTRACT_PUBMED_15534202}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15534202 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15534202}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Immunoglobulin fold]] | | [[Category: Immunoglobulin fold]] |
| [[Category: Ucht1-scfv]] | | [[Category: Ucht1-scfv]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:05:20 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:27:12 2008'' |
