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| [[Image:2ns3.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2ns3| PDB=2ns3 | SCENE= }} | | {{STRUCTURE_2ns3| PDB=2ns3 | SCENE= }} |
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| '''Solution structure of ribbon BuIA'''
| | ===Solution structure of ribbon BuIA=== |
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| ==Overview==
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| BACKGROUND: Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin. RESULTS: In the current study we show the native globular disulfide connectivity of BuIA displays multiple conformations in solution whereas the non-native ribbon isomer has a single well-defined conformation. Despite having multiple conformations in solution the globular form of BuIA displays activity at the nicotinic acetylcholine receptor, contrasting with the lack of activity of the structurally well-defined ribbon isomer. CONCLUSION: These findings are opposite to the general trends observed for alpha-conotoxins where the native isomers have well-defined structures and the ribbon isomers are generally disordered. This study thus highlights the influence of the disulfide connectivity of BuIA on the dynamics of the three-dimensional structure.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17445276}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17445276 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17445276}} |
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| ==About this Structure== | | ==About this Structure== |
| 2NS3 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS3 OCA]. | | 2NS3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS3 OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Ribbon disulfide connectivity]] | | [[Category: Ribbon disulfide connectivity]] |
| [[Category: Toxin]] | | [[Category: Toxin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:29 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:28:53 2008'' |
