2j8o: Difference between revisions

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~~'''~~STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169~~'''~~

===STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169===

~~==Overview==~~

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Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin. Here, ~~we present the molecular structure of a tandem arrangement of two immunoglobulin-like domains~~, ~~A168 and A169, located within~~ the ~~A-band segment of titin. The two domains are connected by a 17 residue long beta-strand and form a common interface. Based on these data, we establish general principles~~ to ~~estimate~~ the ~~amount of conformational flexibility of tandem domain motifs in titin~~. ~~An unusual bulge within the second domain, A169~~, is ~~directly involved into binding to a sarcomeric ligand, MURF-1, thus suggesting a dual role of this tandem for both~~ the ~~mechanical properties of titin and for sarcomeric signaling~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17574571}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17574571 is the PubMed ID number.

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==About this Structure==

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[[Category: Transferase]]

[[Category: Wd repeat]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 08~~:30:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:46:15 2008''

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-[[Image:2j8o.jpg|left|200px]]
+{{Seed}}
+[[Image:2j8o.png|left|200px]]
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 {{STRUCTURE_2j8o|  PDB=2j8o  |  SCENE=  }}
-'''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169'''
+===STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169===
-==Overview==
+<!--
-Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin. Here, we present the molecular structure of a tandem arrangement of two immunoglobulin-like domains, A168 and A169, located within the A-band segment of titin. The two domains are connected by a 17 residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational flexibility of tandem domain motifs in titin. An unusual bulge within the second domain, A169, is directly involved into binding to a sarcomeric ligand, MURF-1, thus suggesting a dual role of this tandem for both the mechanical properties of titin and for sarcomeric signaling.
+The line below this paragraph, {{ABSTRACT_PUBMED_17574571}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17574571 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17574571}}
 ==About this Structure==
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 [[Category: Transferase]]
 [[Category: Wd repeat]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:30:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:46:15 2008''