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[[Image:1yyb.gif|left|200px]]
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[[Image:1yyb.png|left|200px]]


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{{STRUCTURE_1yyb|  PDB=1yyb  |  SCENE=  }}  
{{STRUCTURE_1yyb|  PDB=1yyb  |  SCENE=  }}  


'''Solution structure of 1-26 fragment of human programmed cell death 5 protein'''
===Solution structure of 1-26 fragment of human programmed cell death 5 protein===




==Overview==
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PDCD5-(1-26) is a N-terminal 26-residue fragment of human PDCD5 (programmed cell death 5) protein. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. The conformation of PDCD5 protein is a stable helical core consisting of a triple-helix bundle and two dissociated terminal regions. The N-terminal region is ordered and contains abundant secondary structure. Overexpression and purification of the N-terminal 26-residure fragment, PDCD5-(1-26), was performed in this study to better understand its tertiary structure. The spectroscopic studies using CD and hetero- and homo-nuclear NMR methods determine a stable alpha-helix formed by Asp3-Ala19 of PDCD5-(1-26). The N-terminal residues Asp3-Ala19 of PDCD5 were then affirmed to have the capacity to form a stable alpha-helix independently of the core of the protein. Analysis of the helical peptide of PDCD5-(1-26) indicates that the surface of this well-formed alpha-helix has a unique electrostatic potential character. This may provide an environment for the N-terminal alpha-helix of PDCD5 to serve as an independent functional entity of the protein. The apoptosis activity assay shows that the deletion of the N-terminal alpha-helix of PDCD5 significantly attenuates the apoptosis-promoting effects on HL-60 cells induced by serum withdrawal.
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{{ABSTRACT_PUBMED_16083422}}


==About this Structure==
==About this Structure==
1YYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA].  
1YYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA].  


==Reference==
==Reference==
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[[Category: Yao, H W.]]
[[Category: Yao, H W.]]
[[Category: Solution structure]]
[[Category: Solution structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:57:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:47:40 2008''

Revision as of 15:47, 27 July 2008

File:1yyb.png

Template:STRUCTURE 1yyb

Solution structure of 1-26 fragment of human programmed cell death 5 protein

Template:ABSTRACT PUBMED 16083422

About this Structure

1YYB is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character., Liu D, Yao H, Chen Y, Feng Y, Chen Y, Wang J, Biochem J. 2005 Nov 15;392(Pt 1):47-54. PMID:16083422

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