1ttg: Difference between revisions

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[[Image:1ttg.gif|left|200px]]
{{Seed}}
[[Image:1ttg.png|left|200px]]


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{{STRUCTURE_1ttg|  PDB=1ttg  |  SCENE=  }}  
{{STRUCTURE_1ttg|  PDB=1ttg  |  SCENE=  }}  


'''THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS'''
===THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS===




==Overview==
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The solution structure of the tenth type III module of fibronectin has been determined using nuclear magnetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven beta strands forming two antiparallel beta sheets, which pack against each other. Both beta sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.
The line below this paragraph, {{ABSTRACT_PUBMED_1423622}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 1423622 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1423622}}


==About this Structure==
==About this Structure==
1TTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTG OCA].  
1TTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTG OCA].  


==Reference==
==Reference==
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[[Category: Main, A L.]]
[[Category: Main, A L.]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:20:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:16:45 2008''

Revision as of 16:16, 27 July 2008

File:1ttg.png

Template:STRUCTURE 1ttg

THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS

Template:ABSTRACT PUBMED 1423622

About this Structure

1TTG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions., Main AL, Harvey TS, Baron M, Boyd J, Campbell ID, Cell. 1992 Nov 13;71(4):671-8. PMID:1423622

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