2jpp: Difference between revisions

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[[Image:2jpp.gif|left|200px]]
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[[Image:2jpp.png|left|200px]]


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{{STRUCTURE_2jpp|  PDB=2jpp  |  SCENE=  }}  
{{STRUCTURE_2jpp|  PDB=2jpp  |  SCENE=  }}  


'''Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA'''
===Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA===




==Overview==
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Proteins of the RsmA/CsrA family are global translational regulators in many bacterial species. We have determined the solution structure of a complex formed between the RsmE protein, a member of this family from Pseudomonas fluorescens, and a target RNA encompassing the ribosome-binding site of the hcnA gene. The RsmE homodimer with its two RNA-binding sites makes optimal contact with an 5'-A/UCANGGANGU/A-3' sequence in the mRNA. When tightly gripped by RsmE, the ANGGAN core folds into a loop, favoring the formation of a 3-base-pair stem by flanking nucleotides. We validated these findings by in vivo and in vitro mutational analyses. The structure of the complex explains well how, by sequestering the Shine-Dalgarno sequence, the RsmA/CsrA proteins repress translation.
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{{ABSTRACT_PUBMED_17704818}}


==About this Structure==
==About this Structure==
2JPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPP OCA].  
2JPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPP OCA].  


==Reference==
==Reference==
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[[Category: Shine-dalgarno]]
[[Category: Shine-dalgarno]]
[[Category: Translation/rna complex]]
[[Category: Translation/rna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:09:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:39:46 2008''

Revision as of 16:39, 27 July 2008

File:2jpp.png

Template:STRUCTURE 2jpp

Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA

Template:ABSTRACT PUBMED 17704818

About this Structure

2JPP is a Single protein structure of sequence from Pseudomonas fluorescens. Full experimental information is available from OCA.

Reference

Molecular basis of messenger RNA recognition by the specific bacterial repressing clamp RsmA/CsrA., Schubert M, Lapouge K, Duss O, Oberstrass FC, Jelesarov I, Haas D, Allain FH, Nat Struct Mol Biol. 2007 Sep;14(9):807-13. Epub 2007 Aug 19. PMID:17704818

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