2auc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2auc.gif|left|200px]]
{{Seed}}
[[Image:2auc.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2auc|  PDB=2auc  |  SCENE=  }}  
{{STRUCTURE_2auc|  PDB=2auc  |  SCENE=  }}  


'''Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor'''
===Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor===




==Overview==
<!--
The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.
The line below this paragraph, {{ABSTRACT_PUBMED_16547135}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16547135 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16547135}}


==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomics of pathogenic protozoa consortium]]
[[Category: Structural genomics of pathogenic protozoa consortium]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:29:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:02:13 2008''
Retrieved from "https://proteopedia.org/2auc"