1jac: Difference between revisions

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[[Image:1jac.~~gif~~|left|200px]]

[[Image:1jac.png|left|200px]]

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~~'''~~A NOVEL MODE OF CARBOHYDRATE RECOGNITION IN JACALIN, A MORACEAE PLANT LECTIN WITH A BETA-PRISM~~'''~~

===A NOVEL MODE OF CARBOHYDRATE RECOGNITION IN JACALIN, A MORACEAE PLANT LECTIN WITH A BETA-PRISM===

~~==Overview==~~

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~~Jacalin~~, ~~a tetrameric two-chain lectin (66~~,~~000 Mr) from jackfruit seeds, is highly specific for~~ the ~~tumour associated T-antigenic disaccharide~~. ~~The crystal structure of jacalin with methyl-alpha-D-galactose reveals that each subunit has a three-fold symmetric beta-prism fold made up of three four-stranded beta-sheets~~. ~~The lectin exhibits a novel carbohydrate-binding site involving the N terminus of the alpha-chain which is generated through a post-translational modification involving proteolysis~~, ~~the first known instance~~ where ~~such a modification has been used to confer carbohydrate specificity. This new lectin fold may be characteristic of~~ the ~~Moraceae plant family~~. ~~The structure provides an explanation for the relative affinities of the lectin for galactose derivatives and provides insights into the structural basis of its T~~-~~antigen specificity.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8673603}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8673603 is the PubMed ID number.

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==About this Structure==

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[[Category: Lectin]]

[[Category: Non-legume]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2~~ 20:58:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:03:35 2008''

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-[[Image:1jac.gif|left|200px]]
+{{Seed}}
+[[Image:1jac.png|left|200px]]
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 {{STRUCTURE_1jac|  PDB=1jac  |  SCENE=  }}
-'''A NOVEL MODE OF CARBOHYDRATE RECOGNITION IN JACALIN, A MORACEAE PLANT LECTIN WITH A BETA-PRISM'''
+===A NOVEL MODE OF CARBOHYDRATE RECOGNITION IN JACALIN, A MORACEAE PLANT LECTIN WITH A BETA-PRISM===
-==Overview==
+<!--
-Jacalin, a tetrameric two-chain lectin (66,000 Mr) from jackfruit seeds, is highly specific for the tumour associated T-antigenic disaccharide. The crystal structure of jacalin with methyl-alpha-D-galactose reveals that each subunit has a three-fold symmetric beta-prism fold made up of three four-stranded beta-sheets. The lectin exhibits a novel carbohydrate-binding site involving the N terminus of the alpha-chain which is generated through a post-translational modification involving proteolysis, the first known instance where such a modification has been used to confer carbohydrate specificity. This new lectin fold may be characteristic of the Moraceae plant family. The structure provides an explanation for the relative affinities of the lectin for galactose derivatives and provides insights into the structural basis of its T-antigen specificity.
+The line below this paragraph, {{ABSTRACT_PUBMED_8673603}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8673603 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8673603}}
 ==About this Structure==
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 [[Category: Lectin]]
 [[Category: Non-legume]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:58:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:03:35 2008''