1ptr: Difference between revisions

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[[Image:1ptr.~~gif~~|left|200px]]

[[Image:1ptr.png|left|200px]]

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~~'''~~PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE~~'''~~

===PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE===

~~==Overview==~~

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~~Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters.~~ The ~~structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate~~, ~~which binds in a groove between two pulled-apart beta strands at~~ the ~~tip of~~ the ~~domain~~. ~~The C3, C4~~, ~~and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation~~ is ~~controlled by a set of highly conserved residues~~. ~~Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one~~-~~third of the domain, explaining how the activator promotes insertion of PKC into membranes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7781068}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7781068 is the PubMed ID number.

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==About this Structure==

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[[Category: Zhang, G.]]

[[Category: Phosphotransferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:28:25 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:04:01 2008''

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-[[Image:1ptr.gif|left|200px]]
+{{Seed}}
+[[Image:1ptr.png|left|200px]]
 <!--
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 {{STRUCTURE_1ptr|  PDB=1ptr  |  SCENE=  }}
-'''PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE'''
+===PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE===
-==Overview==
+<!--
-Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes.
+The line below this paragraph, {{ABSTRACT_PUBMED_7781068}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7781068 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7781068}}
 ==About this Structure==
@@ Line 25: / Line 29: @@
 [[Category: Zhang, G.]]
 [[Category: Phosphotransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:28:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:04:01 2008''