2g31: Difference between revisions

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[[Image:2g31.gif|left|200px]]
{{Seed}}
[[Image:2g31.png|left|200px]]


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{{STRUCTURE_2g31|  PDB=2g31  |  SCENE=  }}  
{{STRUCTURE_2g31|  PDB=2g31  |  SCENE=  }}  


'''Human Nogo-A functional domain: nogo60'''
===Human Nogo-A functional domain: nogo60===




==Overview==
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The inability to determine the structure of the buffer-insoluble Nogo extracellular domain retarded further design of Nogo receptor (NgR) antagonists to treat CNS axonal injuries. Very surprisingly, we recently discovered that Nogo-60 was soluble and structured in salt-free water, thus allowing the determination of the first Nogo structure by heteronuclear NMR spectroscopy. Nogo-60 adopts an unusual helical structure with the N- and C-terminal helices connected by a long middle helix. While the N-helix has no contact with the rest of the molecule, the C-helix flips back to pack against the 20-residue middle helix. This packing appears to trigger the formation of the stable Nogo-60 structure because Nogo-40 with the last helix truncated is unstructured. The Nogo-60 structure offered us rationales for further design of the structured and buffer-soluble Nogo-54, which may be used as a novel NgR antagonist. Furthermore, our discovery may imply a general solution to solubilizing a category of buffer-insoluble proteins for urgent structural investigations.
The line below this paragraph, {{ABSTRACT_PUBMED_16877707}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16877707 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16877707}}


==About this Structure==
==About this Structure==
2G31 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G31 OCA].  
2G31 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G31 OCA].  


==Reference==
==Reference==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Nogo]]
[[Category: Nogo]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:37:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:10:39 2008''

Revision as of 17:10, 27 July 2008

File:2g31.png

Template:STRUCTURE 2g31

Human Nogo-A functional domain: nogo60

Template:ABSTRACT PUBMED 16877707

About this Structure

2G31 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration., Li M, Liu J, Song J, Protein Sci. 2006 Aug;15(8):1835-41. PMID:16877707

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