1ny7: Difference between revisions

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[[Image:1ny7.gif|left|200px]]
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[[Image:1ny7.png|left|200px]]


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{{STRUCTURE_1ny7|  PDB=1ny7  |  SCENE=  }}  
{{STRUCTURE_1ny7|  PDB=1ny7  |  SCENE=  }}  


'''COWPEA MOSAIC VIRUS (CPMV)'''
===COWPEA MOSAIC VIRUS (CPMV)===




==Overview==
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Comoviruses are a group of plant viruses in the picornavirus superfamily. The type member of comoviruses, cowpea mosaic virus (CPMV), was crystallized in the cubic space group I23, a = 317 A and the hexagonal space group P6(1)22, a = 451 A, c = 1038 A. Structures of three closely similar nucleoprotein particles were determined in the cubic form. The roughly 300-A capsid was similar to the picornavirus capsid displaying a pseudo T = 3 (P = 3) surface lattice. The three beta-sandwich domains adopt two orientations, one with the long axis radial and the other two with the long axes tangential in reference to the capsid sphere. T = 3 viruses display one or the other of these two orientations. The CPMV capsid was permeable to cesium ions, leading to a disturbance of the beta-annulus inside a channel-like structure, suggesting an ion channel. The hexagonal crystal form diffracted X rays to 3 A resolution, despite the large unit cell. The large ( approximately 200 A) solvent channels in the lattice allow exchange of CPMV cognate Fab fragments. As an initial step in the structure determination of the CPMV/Fab complex, the P6(1)22 crystal structure was solved by molecular replacement with the CPMV model determined in the cubic cell.
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{{ABSTRACT_PUBMED_10603314}}


==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Virus]]
[[Category: Virus]]
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Revision as of 17:11, 27 July 2008

File:1ny7.png

Template:STRUCTURE 1ny7

COWPEA MOSAIC VIRUS (CPMV)

Template:ABSTRACT PUBMED 10603314

About this Structure

1NY7 is a Protein complex structure of sequences from Cowpea mosaic virus. Full crystallographic information is available from OCA.

Reference

The refined crystal structure of cowpea mosaic virus at 2.8 A resolution., Lin T, Chen Z, Usha R, Stauffacher CV, Dai JB, Schmidt T, Johnson JE, Virology. 1999 Dec 5;265(1):20-34. PMID:10603314

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