1tkx: Difference between revisions

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[[Image:1tkx.gif|left|200px]]
{{Seed}}
[[Image:1tkx.png|left|200px]]


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{{STRUCTURE_1tkx|  PDB=1tkx  |  SCENE=  }}  
{{STRUCTURE_1tkx|  PDB=1tkx  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''
===CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745===




==Overview==
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HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_15537347}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15537347}}


==About this Structure==
==About this Structure==
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[[Category: Hiv-1 reverse transcriptase]]
[[Category: Hiv-1 reverse transcriptase]]
[[Category: Nnrti]]
[[Category: Nnrti]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:04:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:24:16 2008''
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