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| {{STRUCTURE_2cc3| PDB=2cc3 | SCENE= }} | | {{STRUCTURE_2cc3| PDB=2cc3 | SCENE= }} |
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| '''STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN'''
| | ===STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN=== |
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| ==Overview==
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| Bacterial type IV secretion systems (T4SS) translocate DNA and/or proteins to recipient cells, thus providing a mechanism for conjugative transfer of genetic material and bacterial pathogenesis. Here we describe the first structure of a core component from the archetypal Agrobacterium tumefaciens T4SS: the 2.2-A resolution crystal structure of the VirB8 periplasmic domain (pVirB8(AT)). VirB8 forms a dimer in the crystal, and we identify residues likely important for stabilization of the dimer interface. Structural comparison of pVirB8(AT) with Brucella suis VirB8 confirms that the monomers have a similar fold. In addition, the pVirB8(AT) dimer superimposes very closely on the B. suis VirB8 dimer, supporting the proposal that dimer formation in the crystal reflects self-interactions that are biologically significant. The evolutionary conservation level for each residue was obtained from a data set of 84 VirB8 homologs and projected onto the protein structure to indicate conserved surface patches that likely contact other T4SS proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16481621}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16481621 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16481621}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Type iv secretion system]] | | [[Category: Type iv secretion system]] |
| [[Category: Virb8]] | | [[Category: Virb8]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:44:52 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:43:01 2008'' |
