2i5d: Difference between revisions

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~~'''~~Crystal Structure of Human Inosine Triphosphate Pyrophosphatase~~'''~~

===Crystal Structure of Human Inosine Triphosphate Pyrophosphatase===

~~==Overview==~~

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The ~~structure of human inosine triphosphate pyrophosphohydrolase (ITPA) has been determined using diffraction data to 1.6 A resolution. ITPA contributes~~ to the ~~accurate replication of DNA by cleansing cellular dNTP pools of mutagenic nucleotide purine analogs such~~ as ~~dITP or dXTP~~. ~~A similar high-resolution unpublished structure has been deposited in the Protein Data Bank from a monoclinic and pseudo-merohedrally twinned crystal~~. ~~Here~~, ~~cocrystallization of ITPA with a molar ratio of XTP appears to have improved~~ the ~~crystals by eliminating twinning and resulted in an orthorhombic space group~~. ~~However, there was no evidence for bound XTP in the structure. Comparison with substrate~~-~~bound NTPase from a thermophilic organism predicts the movement of residues within helix alpha1, the loop before alpha6 and helix alpha7 to cap off the active site when substrate is bound.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17077483}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17077483 is the PubMed ID number.

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==About this Structure==

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[[Category: Porta, J C.]]

[[Category: Monomeric protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 07~~:05:31 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:46:21 2008''

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-[[Image:2i5d.gif|left|200px]]
+{{Seed}}
+[[Image:2i5d.png|left|200px]]
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 {{STRUCTURE_2i5d|  PDB=2i5d  |  SCENE=  }}
-'''Crystal Structure of Human Inosine Triphosphate Pyrophosphatase'''
+===Crystal Structure of Human Inosine Triphosphate Pyrophosphatase===
-==Overview==
+<!--
-The structure of human inosine triphosphate pyrophosphohydrolase (ITPA) has been determined using diffraction data to 1.6 A resolution. ITPA contributes to the accurate replication of DNA by cleansing cellular dNTP pools of mutagenic nucleotide purine analogs such as dITP or dXTP. A similar high-resolution unpublished structure has been deposited in the Protein Data Bank from a monoclinic and pseudo-merohedrally twinned crystal. Here, cocrystallization of ITPA with a molar ratio of XTP appears to have improved the crystals by eliminating twinning and resulted in an orthorhombic space group. However, there was no evidence for bound XTP in the structure. Comparison with substrate-bound NTPase from a thermophilic organism predicts the movement of residues within helix alpha1, the loop before alpha6 and helix alpha7 to cap off the active site when substrate is bound.
+The line below this paragraph, {{ABSTRACT_PUBMED_17077483}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17077483 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17077483}}
 ==About this Structure==
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 [[Category: Porta, J C.]]
 [[Category: Monomeric protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:05:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:46:21 2008''