2v8n: Difference between revisions

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[[Image:2v8n.jpg|left|200px]]
{{Seed}}
[[Image:2v8n.png|left|200px]]


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{{STRUCTURE_2v8n|  PDB=2v8n  |  SCENE=  }}  
{{STRUCTURE_2v8n|  PDB=2v8n  |  SCENE=  }}  


'''WILD-TYPE STRUCTURE OF LACTOSE PERMEASE'''
===WILD-TYPE STRUCTURE OF LACTOSE PERMEASE===




==Overview==
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Here we describe an x-ray structure of wild-type lactose permease (LacY) from Escherichia coli determined by manipulating phospholipid content during crystallization. The structure exhibits the same global fold as the previous x-ray structures of a mutant that binds sugar but cannot catalyze translocation across the membrane. LacY is organized into two six-helix bundles with twofold pseudosymmetry separated by a large interior hydrophilic cavity open only to the cytoplasmic side and containing the side chains important for sugar and H(+) binding. To initiate transport, binding of sugar and/or an H(+) electrochemical gradient increases the probability of opening on the periplasmic side. Because the inward-facing conformation represents the lowest free-energy state, the rate-limiting step for transport may be the conformational change leading to the outward-facing conformation.
The line below this paragraph, {{ABSTRACT_PUBMED_17881559}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17881559}}


==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Transport protein]]
[[Category: Transport protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:22:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:02:29 2008''

Revision as of 18:02, 27 July 2008

File:2v8n.png

Template:STRUCTURE 2v8n

WILD-TYPE STRUCTURE OF LACTOSE PERMEASE

Template:ABSTRACT PUBMED 17881559

About this Structure

2V8N is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural determination of wild-type lactose permease., Guan L, Mirza O, Verner G, Iwata S, Kaback HR, Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15294-8. Epub 2007 Sep 19. PMID:17881559

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