1qgr: Difference between revisions

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[[Image:1qgr.gif|left|200px]]
{{Seed}}
[[Image:1qgr.png|left|200px]]


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{{STRUCTURE_1qgr|  PDB=1qgr  |  SCENE=  }}  
{{STRUCTURE_1qgr|  PDB=1qgr  |  SCENE=  }}  


'''STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH)'''
===STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH)===




==Overview==
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Cytosolic proteins bearing a classical nuclear localization signal enter the nucleus bound to a heterodimer of importin-alpha and importin-beta (also called karyopherin-alpha and -beta). The formation of this heterodimer involves the importin-beta-binding (IBB) domain of importin-alpha, a highly basic amino-terminal region of roughly 40 amino-acid residues. Here we report the crystal structure of human importin-beta bound to the IBB domain of importin-alpha, determined at 2.5 A and 2.3 A resolution in two crystal forms. Importin-beta consists of 19 tandemly repeated HEAT motifs and wraps intimately around the IBB domain. The association involves two separate regions of importin-beta, recognizing structurally distinct parts of the IBB domain: an amino-terminal extended moiety and a carboxy-terminal helix. The structure indicates that significant conformational changes occur when importin-beta binds or releases the IBB domain domain and suggests how dissociation of the importin-alpha/beta heterodimer may be achieved upon nuclear entry.
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{{ABSTRACT_PUBMED_10353244}}


==About this Structure==
==About this Structure==
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[[Category: Nuclear import]]
[[Category: Nuclear import]]
[[Category: Transport receptor]]
[[Category: Transport receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:15:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:03:29 2008''

Revision as of 18:03, 27 July 2008

File:1qgr.png

Template:STRUCTURE 1qgr

STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH)

Template:ABSTRACT PUBMED 10353244

About this Structure

1QGR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of importin-beta bound to the IBB domain of importin-alpha., Cingolani G, Petosa C, Weis K, Muller CW, Nature. 1999 May 20;399(6733):221-9. PMID:10353244

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