2gv2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
Line 1: Line 1:
[[Image:2gv2.gif|left|200px]]
{{Seed}}
[[Image:2gv2.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2gv2|  PDB=2gv2  |  SCENE=  }}  
{{STRUCTURE_2gv2|  PDB=2gv2  |  SCENE=  }}  


'''MDM2 in complex with an 8-mer p53 peptide analogue'''
===MDM2 in complex with an 8-mer p53 peptide analogue===




==Overview==
<!--
The most potent inhibitor of the p53-MDM2 interaction reported to date is an 8-mer p53 peptide analogue (Novartis peptide), which contains 6-chlorotryptophane (Cl-Trp) and phosphonomethylphenylalanine (Pmp) as key residues for the enhanced activity. We report here a crystal structure of the co-complex between MDM2 and the Novartis peptide solved at 1.8 A resolution. The structural basis for the role of the two aromatic residues are delineated by comparing the present structure with crystal structures of the MDM2 co-complex bound to other inhibitors including the wt-p53 peptide itself.
The line below this paragraph, {{ABSTRACT_PUBMED_16925398}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16925398 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16925398}}


==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Schubert, C.]]
[[Category: Schubert, C.]]
[[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
[[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:34:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:05:59 2008''

Revision as of 18:06, 27 July 2008

File:2gv2.png

Template:STRUCTURE 2gv2

MDM2 in complex with an 8-mer p53 peptide analogue

Template:ABSTRACT PUBMED 16925398

About this Structure

2GV2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2., Sakurai K, Schubert C, Kahne D, J Am Chem Soc. 2006 Aug 30;128(34):11000-1. PMID:16925398

Page seeded by OCA on Sun Jul 27 21:05:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA