2ho6: Difference between revisions

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[[Image:2ho6.gif|left|200px]]
{{Seed}}
[[Image:2ho6.png|left|200px]]


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{{STRUCTURE_2ho6|  PDB=2ho6  |  SCENE=  }}  
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'''Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''
===Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===




==Overview==
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The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
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{{ABSTRACT_PUBMED_16990543}}


==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Rna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:30:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:19:52 2008''

Revision as of 18:19, 27 July 2008

File:2ho6.png

Template:STRUCTURE 2ho6

Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme

Template:ABSTRACT PUBMED 16990543

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543

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