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| [[Image:1pex.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1pex| PDB=1pex | SCENE= }} | | {{STRUCTURE_1pex| PDB=1pex | SCENE= }} |
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| '''COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN'''
| | ===COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN=== |
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| ==Overview==
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| Collagenase-3 (MMP-13) is a matrix metalloproteinase involved in human breast cancer pathology and in arthritic processes. The crystal structure of its C-terminal haemopexin-like domain has been solved by molecular replacement and refined to an R-value of 0.195 using data to 2.7 A resolution. This structure reveals a disk-like shape. The chain is folded into a beta-propeller structure of pseudo 4-fold symmetry, with the four propeller blades arranged around a funnel-like tunnel. This central tunnel tube harbours four ions assigned as two calcium and two chloride ions. The C-terminal domain of collagenase-3 has a similar structure to the equivalent domain of gelatinase A and fibroblast collagenase 1; however, its detailed structure and surface charge pattern has a somewhat greater similarity to the latter, in agreement with the subgrouping of MMP-13 with the collagenase subfamily of MMPs. It is proposed that several small structural differences may act together to confer the characteristic binding and cleavage specificities of collagenases for triple-helical substrates, probably in co-operation with a fitting interdomain linker.
| | The line below this paragraph, {{ABSTRACT_PUBMED_8969305}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8969305 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8969305}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Murphy, G.]] | | [[Category: Murphy, G.]] |
| [[Category: C-terminal hemopexin-like domain of matrix-metalloproteinase]] | | [[Category: C-terminal hemopexin-like domain of matrix-metalloproteinase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:00:37 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:22:52 2008'' |
