1tf2: Difference between revisions

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[[Image:1tf2.jpg|left|200px]]
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{{STRUCTURE_1tf2|  PDB=1tf2  |  SCENE=  }}  
{{STRUCTURE_1tf2|  PDB=1tf2  |  SCENE=  }}  


'''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''
===Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis===




==Overview==
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The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.
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{{ABSTRACT_PUBMED_15256599}}


==About this Structure==
==About this Structure==
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[[Category: Secretion]]
[[Category: Secretion]]
[[Category: Translocation]]
[[Category: Translocation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:52:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:31:38 2008''

Revision as of 19:31, 27 July 2008

File:1tf2.png

Template:STRUCTURE 1tf2

Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis

Template:ABSTRACT PUBMED 15256599

About this Structure

1TF2 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

A large conformational change of the translocation ATPase SecA., Osborne AR, Clemons WM Jr, Rapoport TA, Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15. PMID:15256599

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