2c0m: Difference between revisions

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[[Image:2c0m.jpg|left|200px]]
{{Seed}}
[[Image:2c0m.png|left|200px]]


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{{STRUCTURE_2c0m|  PDB=2c0m  |  SCENE=  }}  
{{STRUCTURE_2c0m|  PDB=2c0m  |  SCENE=  }}  


'''APO FORM OF THE TPR DOMAIN OF THE PEX5P RECEPTOR'''
===APO FORM OF THE TPR DOMAIN OF THE PEX5P RECEPTOR===




==Overview==
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Peroxisomes require the translocation of folded and functional target proteins of various sizes across the peroxisomal membrane. We have investigated the structure and function of the principal import receptor Pex5p, which recognizes targets bearing a C-terminal peroxisomal targeting signal type 1. Crystal structures of the receptor in the presence and absence of a peroxisomal target, sterol carrier protein 2, reveal major structural changes from an open, snail-like conformation into a closed, circular conformation. These changes are caused by a long loop C terminal to the 7-fold tetratricopeptide repeat segments. Mutations in residues of this loop lead to defects in peroxisomal import in human fibroblasts. The structure of the receptor/cargo complex demonstrates that the primary receptor-binding site of the cargo is structurally and topologically autonomous, enabling the cargo to retain its native structure and function.
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{{ABSTRACT_PUBMED_17157249}}


==About this Structure==
==About this Structure==
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[[Category: Transport protein]]
[[Category: Transport protein]]
[[Category: Zellweger syndrome]]
[[Category: Zellweger syndrome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:03:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:44:57 2008''

Revision as of 19:44, 27 July 2008

File:2c0m.png

Template:STRUCTURE 2c0m

APO FORM OF THE TPR DOMAIN OF THE PEX5P RECEPTOR

Template:ABSTRACT PUBMED 17157249

About this Structure

2C0M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p., Stanley WA, Filipp FV, Kursula P, Schuller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M, Mol Cell. 2006 Dec 8;24(5):653-63. PMID:17157249

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