2hvz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2hvz.gif|left|200px]]
{{Seed}}
[[Image:2hvz.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hvz|  PDB=2hvz  |  SCENE=  }}  
{{STRUCTURE_2hvz|  PDB=2hvz  |  SCENE=  }}  


'''Solution structure of the RRM domain of SR rich factor 9G8'''
===Solution structure of the RRM domain of SR rich factor 9G8===




==Overview==
<!--
The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing. They also play a role in mRNA export, in particular of histone mRNAs. We present the solution structures of the free 9G8 and SRp20 RNA recognition motifs (RRMs) and of SRp20 RRM in complex with the RNA sequence 5'CAUC3'. The SRp20-RNA structure reveals that although all 4 nt are contacted by the RRM, only the 5' cytosine is primarily recognized in a specific way. This might explain the numerous consensus sequences found by SELEX (systematic evolution of ligands by exponential enrichment) for the RRM of 9G8 and SRp20. Furthermore, we identify a short arginine-rich peptide adjacent to the SRp20 and 9G8 RRMs, which does not contact RNA but is necessary and sufficient for interaction with the export factor Tip-associated protein (TAP). Together, these results provide a molecular description for mRNA and TAP recognition by SRp20 and 9G8.
The line below this paragraph, {{ABSTRACT_PUBMED_17036044}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17036044 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17036044}}


==About this Structure==
==About this Structure==
2HVZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA].  
2HVZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA].  


==Reference==
==Reference==
Line 28: Line 32:
[[Category: Wilson, S A.]]
[[Category: Wilson, S A.]]
[[Category: Rrm]]
[[Category: Rrm]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:46:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:46:12 2008''
Retrieved from "https://proteopedia.org/2hvz"